Remove the crust from the very old, dry, hard-as-a-rock bread and discard it. Cut into slices and then cubes -- allow bread to set until it is rock hard.
In a large mixing bowl, soak the bread in milk and water for 30 minutes to soften the bread, before mixing it in the ground meat mixture.
With your hands (use plastic gloves and/or clean hands), take the bread that has been soaking in the milk & water and squeeze out all of the milk and water. Place the moist bread on a plate and set aside. Discard the milk water.
Combine the softened, moist breadcrumbs with the ground meats, prosciutto, and pancetta in a large bowl.
Using clean hands or with plastic gloves: In a large mixing bowl, combine the Parmigiano-Reggiano cheese, onion & juice, Italian parsley, eggs, garlic, basil, Italian seasoning, salt, and pepper. Using clean hands (or wear plastic gloves), mix everything to combine thoroughly.
Now combine the meat/breadcrumb mixture to the chese, egg, and herb mixture that you just mixed together. IMPORTANT: Use only the tips of your fingers to combine the ingredients so that you do NOT overwork the mixture, which causes the meatballs to be heavy and hard.
Place some flour on a clean plate for dredging the meatballs.
After combining all of the meatball ingredients, take a small amount of the mixture and roll it into 2" round ball shapes, in the flour. Use a scoop if you prefer for consistency in size, but Mamma Agata did not use a scoop.
Roll the meatballs in the flour. Shake off any excess. Place them on a clean plate. Repeat this process until all of the meat mixture is made into meatballs.
Place the floured meatballs onto a baking sheet pan and cover with plastic cling wrap. Refrigerate the meatballs for at least 1 hour or overnight. This allows the fat in the meats to solidify so the meatballs keep their shape when cooked.
Fry, bake, or sear the meatballs and then bake in tomato saucer according to (separate) instructions.